3’-dC(Bz)-2’-phosphor amidite

Names

[ Name ]:
3’-dC(Bz)-2’-phosphor amidite

[Synonym ]:
Midostaurin
4'-N-benzoyl staurosprine
Benzoylstaurosporine
Cgp 41 251
4'-N-benzoylstaurosporine

Biological Activity

[Description]:

3’-dC(Bz)-2’-phosphor amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₆H₅₂N₅O₈P

[ Molecular Weight ]:
833.91

[ Exact Mass ]:
833.35500

[ PSA ]:
159.99000

[ LogP ]:
8.54318

3’-dC(Bz)-2’-phosphor amidite

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds