9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine

Names

[ CAS No. ]:
1612191-89-5

[ Name ]:
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine

[Synonym ]:
9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(2-furyl)-9H-purine
9H-Purine, 9-(3-deoxy-3-fluoro-β-D-ribofuranosyl)-6-(2-furanyl)-

Biological Activity

[Description]:

9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(furan-2-yl)purine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
616.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H14N4O5

[ Molecular Weight ]:
318.28

[ Flash Point ]:
326.7±34.3 °C

[ Exact Mass ]:
320.092072

[ LogP ]:
0.81

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.768

Related Compounds