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flutimide

Names

[ CAS No. ]:
162666-34-4

[ Name ]:
flutimide

[Synonym ]:
Flutimide
(3Z)-1-Hydroxy-5-isobutyl-3-(2-methylpropylidene)pyrazine-2,6(1H,3H)-dione
2,6-(1H,3H)-Pyrazinedione,1-hydroxy-5-(2-methylpropyl)-3-(2-methylpropylidene)-,(3Z)

Biological Activity

[Description]:

Flutimide is a novel endonuclease inhibitor of influenza virus. Flutimide selectively inhibits endonuclease with an IC50 value of 3 μM. Flutimide shows antiviral activity in cell culture. Flutimide can be used for the research of acute contagious respiratory disease, such as influenza[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[In Vitro]

Flutimide inhibits the cap-dependent endonuclease of influenza virus with an IC50 value of 3 μM[1].

[References]

[1]. Otto D. Hensens, et al. Isolation and structure of flutimide, a novel endonuclease inhibitor of influenza virus. (1995) 36(12), 2005–2008.

Chemical & Physical Properties

[ Density]:
1.18g/cm3

[ Boiling Point ]:
354.8ºC at 760mmHg

[ Molecular Formula ]:
C12H18N2O3

[ Molecular Weight ]:
238.28300

[ Flash Point ]:
168.4ºC

[ Exact Mass ]:
238.13200

[ PSA ]:
69.97000

[ LogP ]:
1.14490

[ Vapour Pressure ]:
1.86E-06mmHg at 25°C

[ Index of Refraction ]:
1.55

Synthetic Route

Click to get detail synthetic route

Related Compounds