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Penconazole-d7

Names

[ CAS No. ]:
1628110-84-8

[ Name ]:
Penconazole-d7

[Synonym ]:
(±)-Penconazole-d7
CGA 71818-d7
Ofir-d7
Omnex-d7
Topas-d7

Biological Activity

[Description]:

Penconazole-d7 is the deuterium labeled Penconazole[1]. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[2][3].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Neuronal Signaling >> AChE

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8.  

[3]. Chaâbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 201736(8):854-866.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
415.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H8D7CL2N3

[ Molecular Weight ]:
291.23

[ Flash Point ]:
204.9±31.5 °C

[ Exact Mass ]:
290.108246

[ LogP ]:
3.66

[ Appearance of Characters ]:
White to off-white solid

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Storage condition ]:
-20°C

[ Water Solubility ]:
Methanol: slightly soluble

Related Compounds