2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

Names

[ Name ]:
2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

[Synonym ]:
2',3',5'-Tri-O-acetyl-2-amino-6-chloropurine Riboside
2-Amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine
[(2R,3S,4S,5R)-3,4-diacetyloxy-5-(2-amino-6-chloropurin-9-yl)oxolan-2-yl]methyl acetate

Biological Activity

[Description]:

2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.7g/cm3

[ Boiling Point ]:
637ºC at 760mmHg

[ Melting Point ]:
146.0 to 150.0 °C

[ Molecular Formula ]:
C₁₆H₁₈ClN₅O₇

[ Molecular Weight ]:
427.80

[ Flash Point ]:
339ºC

[ Exact Mass ]:
427.08900

[ PSA ]:
157.75000

[ LogP ]:
0.96700

[ Vapour Pressure ]:
4E-16mmHg at 25°C

[ Index of Refraction ]:
1.69

2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds