(Rac)-Nedisertib

Names

[ CAS No. ]:
1637542-34-7

[ Name ]:
(Rac)-Nedisertib

Biological Activity

[Description]:

Rac-Nedisertib (Rac-M3814) is a racemate of Nedisertib, a potent DNA-PK inhibitor, with an IC50 of <3 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK

Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK

[Target]

DNA-PK:<3 nM (IC50)

[In Vitro]

Rac-Nedisertib (Compound 137) potently inhibits DNA-PK, with an IC50 of <3 nM for DNA-PK, 0.5-5 μM for cellular pDNA-PK and 15-25 μM for KV11.1 (hERG, human ether a-go-go related gene) ).[1].

[References]

[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₁ClFN₅O₃

[ Molecular Weight ]:
481.91

[ Storage condition ]:
2-8℃

(Rac)-Nedisertib

Names

Biological Activity

Chemical & Physical Properties

Related Compounds