p38 MAP Kinase Inhibitor IV

Names

[ Name ]:
p38 MAP Kinase Inhibitor IV

[Synonym ]:
p38 MAP Kinase Inhibitor IV
2,2'-Sulfonylbis(3,4,6-trichlorophenol)
Bis-(3,5,6-Trichlor-2-hydroxyphenyl)-sulfon
Bis-(3,5,6-trichlor-2-hydroxyphenyl)sulfid

Biological Activity

[Description]:

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

[Target]

p38α:0.13 μM (IC50)

p38β:0.55 μM (IC50)

p38δ:8.63 μM (IC50)

p38χ:5.47 μM (IC50)

[In Vitro]

p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1].

[References]

[1]. Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352(3):656-661.

Chemical & Physical Properties

[ Density]:
1.854 g/cm3

[ Boiling Point ]:
590ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₄Cl₆O₄S

[ Molecular Weight ]:
456.94100

[ Flash Point ]:
310.6ºC

[ Exact Mass ]:
453.79600

[ PSA ]:
82.98000

[ LogP ]:
6.93180

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2908999090

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%