Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

Names

[ CAS No. ]:
167114-91-2

[ Name ]:
Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

[Synonym ]:
AIP [Ala9]-Autocamtide 2
Autocamtide-2-related inhibitory peptide

Biological Activity

[Description]:

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> CaMK

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

[Target]

IC50: 40 nM (CaMKII)[1].

[In Vitro]

It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1].

[References]

[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₄H₁₁₆N₂₂O₁₉

[ Molecular Weight ]:
1822.12000

[ Exact Mass ]:
1821.07000

[ PSA ]:
746.43000

[ LogP ]:
8.46970

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-36

[ Safety Phrases ]:
22-24/25-26

[ RIDADR ]:
NONH for all modes of transport

Articles

CaMKII Controls Whether Touch Is Painful.

J. Neurosci. 35 , 14086-102, (2015)

The sensation of touch is initiated when fast conducting low-threshold mechanoreceptors (Aβ-LTMRs) generate impulses at their terminals in the skin. Plasticity in this system is evident in the process...

Silanization-Based Zeolite Crystallization: Participation Degree and Pathway.

Chemistry 21 , 12161-70, (2015)

A clear and deep understanding of zeolite crystallization with the addition of organosilane is desirable for the reasonable design and preparation of hierarchical zeolites. Herein, the effects of diff...

Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.

Cardiovasc. Res. 107 , 184-96, (2015)

Enhanced cardiac late Na current (late INa) and increased sarcoplasmic reticulum (SR)-Ca(2+)-leak are both highly arrhythmogenic. This study seeks to identify signalling pathways interconnecting late ...