UK-2A

Names

[ CAS No. ]:
167173-85-5

[ Name ]:
UK-2A

[Synonym ]:
UK-2A
(3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate
Isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester
(3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-di-oxonan-7-yl isobutyrate

Biological Activity

[Description]:

UK-2A (Antibiotic UK 2A) is a potent antifungal antibiotic. UK-2A shows antifungal activity[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

UK-2A (0-100 µg/mL; 24, 48, 120 h) 显示出针抗真菌活性，对 R. mucilaginosa IFO 0001 在 24、48、120 小时的 MIC 值分别为 1.56、>100、>100 µg/mL[2]。

[References]

[1]. Ueki M, et al. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties. J Antibiot (Tokyo). 1996 Jul;49(7):639-43.  

[2]. Tani K, et al. UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J Antibiot (Tokyo). 2002 Mar;55(3):315-21.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H30N2O9

[ Molecular Weight ]:
514.52400

[ Exact Mass ]:
514.19500

[ PSA ]:
150.35000

[ LogP ]:
2.20030

Related Compounds