ARTD10/PARP10-IN-2

Names

[ CAS No. ]:
1708103-69-8

[ Name ]:
ARTD10/PARP10-IN-2

Biological Activity

[Description]:

ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PARP
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

ARTD1/PARP1:9.7 μM (IC50)

ARTD10/PARP10:2.0 μM (IC50)

ARTD8/PARP14:>20 μM (IC50)

ARTD7/PARP15:>20 μM (IC50)


[References]

[1]. Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H13N3O3

[ Molecular Weight ]:
247.25

Related Compounds