5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine

Names

[ Name ]:
5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine

[Synonym ]:
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-2'-O-2-propyn-1-yl-
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-isobutyryl-2'-O-2-propyn-1-ylguanosine

Biological Activity

[Description]:

5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₈H₃₉N₅O₈

[ Molecular Weight ]:
693.74

[ Exact Mass ]:
693.279846

[ LogP ]:
7.66

[ Index of Refraction ]:
1.631