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Carboxycinnamic acid bishydroxamide

Names

[ CAS No. ]:
174664-65-4

[ Name ]:
Carboxycinnamic acid bishydroxamide

[Synonym ]:
N-hydroxy-3-[3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide
Benzamide, N-hydroxy-3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]-
N-Hydroxy-3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide

Biological Activity

[Description]:

m-Carboxycinnamic acid bishydroxamide is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively[1]. m-Carboxycinnamic acid bishydroxamide also induces apoptosis and suppresses tumor growth[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[References]

[1]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

[2]. Glick RD, et al. Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res. 1999 Sep 1;59(17):4392-9.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C10H10N2O4

[ Molecular Weight ]:
222.20

[ Exact Mass ]:
222.064056

[ PSA ]:
98.66000

[ LogP ]:
-0.09

[ Index of Refraction ]:
1.668

Related Compounds