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AN2718

Names

[ CAS No. ]:
174672-06-1

[ Name ]:
AN2718

[Synonym ]:
5-chloro-1,3-dihydro-2,1-benzoxaborol-1-ol
2,1-Benzoxaborole,5-chloro-1,3-dihydro-1-hydroxy
UNII-810U6C2DGG
5-Chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
AN2718

Biological Activity

[Description]:

AN2718 inhibits fungal growth by blocking protein synthesis using the oxaborole tRNA trapping (OBORT) mechanism.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection

[Target]

Fungal[1].


[In Vitro]

AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes[1].

[References]

[1]. Seiradake, et al. Antifungal activity and mechanism of action of a benzoxaborole, AN2718, which is in development for the treatment of tinea pedis. 48th Annual ICAAC/46th Annual IDSA (2008).


[Related Small Molecules]

Cycloheximide | Hygromycin B | Cancidas | 5-Flucytosine | Posaconazole | Terbinafine | Ciclopirox | Isavuconazole | Anidulafungin | Clotrimazole | Clioquinol | Miconazole Nitrate | Pimaricin | Ascomycin | Econazole (nitrate)

Chemical & Physical Properties

[ Molecular Formula ]:
C7H6BClO2

[ Molecular Weight ]:
168.38500

[ Exact Mass ]:
168.01500

[ PSA ]:
29.46000

[ LogP ]:
0.55770

[ Storage condition ]:
2-8℃

Related Compounds