(Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt

(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y1 agonist with a KD of 1.0 nM[1].

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

NPY Y1 receptor:1.0 nM (Kd)

NPY Y2 receptor:670 nM (Kd)

(Leu31,Pro34)-Peptide YY 在大鼠额顶叶皮质膜制剂 (Y1 富集组织) 和兔大隐静脉 (Y1 体外生物测定) 中表现出高亲和力 (nM)，但在 Y2 富集制剂 (大鼠海马) 中仅表现出低亲和力[1]。

(Leu31,Pro34)-Peptide YY (0.1-1 nmol/day; ICV; 14 days) 对大鼠有抗焦虑和抗抑郁作用[2]。 Animal Model: Male Sprague Dawley rats weighing 150-170 g, OBX/Sham model[2] Dosage: 0.1, 0.3 and 1 nmol/day Administration: ICV, for 14 days Result: Significantly decreased hyperlocomotion and immobility time in OBX animals. Reversed the deficit in social contacts in OBX animals. Reduced grooming behavior in sham animals.

[1]. Dumont Y, et al. Peptide YY derivatives as selective neuropeptide Y/peptide YY Y1 and Y2 agonists devoided of activity for the Y3 receptor sub-type. Brain Res Mol Brain Res. 1994 Oct;26(1-2):320-4.  

[2]. Morales-Medina JC, et al. Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Neuropharmacology. 2012 Jan;62(1):200-8.