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PSB-12379

Names

[ CAS No. ]:
1802226-78-3

[ Name ]:
PSB-12379

Biological Activity

[Description]:

PSB-12379 is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Research Areas >> Cancer

[Target]

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]


[References]

[1]. Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63.


[Related Small Molecules]

CGS 21680 hydrochloride | Preladenant | ZM 241385 | CPI-444 | SCH 58261 | Vipadenant | Istradefylline | Tozadenant | AZD-4635 | Capadenoson | 2-CL-IB-MECA | CD73-IN-1 | IB-MECA | Diprophylline | Doxofylline

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23N5O9P2

[ Molecular Weight ]:
515.35

[ Storage condition ]:
2-8℃

Related Compounds