SIRT7 inhibitor 97491
Names
[ CAS No. ]:
1807758-81-1
[ Name ]:
SIRT7 inhibitor 97491
Biological Activity
[Description]:
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].
[Related Catalog]:
[Target]
SIRT7:325 nM (IC50)
[In Vitro]
SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells[1]. Cell Proliferation Assay[1] Cell Line: Human uterine sarcoma MES-SA cells Concentration: 1, 5, 10 μM Incubation Time: 72 hours Result: Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay[1] Cell Line: Human embryonic kidney cell line HEK293 cells Concentration: 1, 5, 10 μM Incubation Time: 24 hours Result: HEK293 cells were almost unaffected.
[In Vivo]
SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1]. Animal Model: Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1] Dosage: 2 mg/kg Administration: Intraperitoneally injected; for 3 weeks, except on weekends. Result: Inhibited cancer growth in vivo.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H12ClN3O
[ Molecular Weight ]:
285.73