NH2-methylpropanamide-Exatecan TFA

Names

[ CAS No. ]:
1817857-35-4

[ Name ]:
NH2-methylpropanamide-Exatecan TFA

Biological Activity

[Description]:

NH2-methylpropanamide-Exatecan TFA is a methylpropanamide-modified Exatecan (HY-13631), which is the common ADC Cytotoxin used in the synthesis of ADC. Exatecan is a DNA topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL), and can be used in cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

[Target]

Topoisomerase I[1]


[References]

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H30F4N4O7

[ Molecular Weight ]:
634.58

Related Compounds