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Tipiracil hydrochloride

Names

[ CAS No. ]:
183204-72-0

[ Name ]:
Tipiracil hydrochloride

[Synonym ]:
Tipiracil HCl
5-amino-1-[(5-chloro-2,6-dihydroxypyrimidin-4-yl)methyl]-3,4-dihydro-2H-pyrrolium chloride
2,4(1H,3H)-Pyrimidinedione, 5-chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-, hydrochloride (1:1)
TAS-1-462
Tipiracil hydrochloride
2H-pyrrolium, 5-amino-1-[(5-chloro-2,6-dihydroxy-4-pyrimidinyl)methyl]-3,4-dihydro-, chloride (1:1)
5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride (1:1)
Tipiracil hydrochloride (JAN)

Biological Activity

[Description]:

Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Cancer

[In Vitro]

Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells[1]. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD[2].

[References]

[1]. Peters GJ, et al. TAS-102: more than an antimetabolite. Lancet Oncol. 2012 Dec;13(12):e518-9.

[2]. Yoshino T, et al. TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial. Lancet Oncol. 2012 Oct;13(10):993-1001.


[Related Small Molecules]

Azacitidine (5-Azacytidine) | Broxuridine | Forodesine (hydrochloride) | Floxuridine | Raltitrexed | Trifluorothymidine | Vidarabine | Clofarabine | Doxifluridine | Nelarabine | 8-Azaguanine | RX-3117 | Tegafur | Tipiracil | LY2334737

Chemical & Physical Properties

[ Molecular Formula ]:
C9H12Cl2N4O2

[ Molecular Weight ]:
279.123

[ Exact Mass ]:
278.033722

[ PSA ]:
93.33000

[ LogP ]:
1.95390

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds