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Heat Shock Protein Inhibitor II

Names

[ CAS No. ]:
1859-42-3

[ Name ]:
Heat Shock Protein Inhibitor II

[Synonym ]:
2-oxo-3-piperonyliden-pyrrolidin
HEAT SHOCK PROTEIN INHIBITOR II
3,4-methylenedioxy-benzylidine-γ-butyrolactam

Biological Activity

[Description]:

KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9.  

[2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H11NO3

[ Molecular Weight ]:
217.22

[ Exact Mass ]:
217.07400

[ PSA ]:
47.56000

[ LogP ]:
1.64740

Related Compounds