BMS 193885

Names

[ Name ]:
BMS 193885

[Synonym ]:
MFCD16878998

Biological Activity

[Description]:

BMS-193885 is a potent, selective, competitive, and brain penetrant neuropeptide Y1 receptor antagonist with a Ki of 3.3 nM, and has an IC50 of 5.9 nM for hY1, which displays > 100, > 160, > 160 and > 160-fold selectivity over α1, hY2, hY4 and hY5 receptors, respectively [1] [2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

Ki: 3.3 nM (Neuropeptide Y1 receptor)[1] IC50: 5.9 nM (hY1)[1]

[References]

[1]. Antal-Zimanyi I, et al. Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist. Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.

[2]. Poindexter GS, et al. Dihydropyridine neuropeptide Y Y(1) receptor antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):379-82.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₄₂N₄O₆

[ Molecular Weight ]:
590.71000

[ Exact Mass ]:
590.31000

[ PSA ]:
121.72000

[ LogP ]:
5.21130

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport