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PF-06700841

Names

[ CAS No. ]:
1883299-62-4

[ Name ]:
PF-06700841

Biological Activity

[Description]:

PF-06700841 is a dual JAK1 and TYK2 inhibitor with IC50s of 17 and 23 nM, respectively. Anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> JAK/STAT Signaling >> JAK

Signaling Pathways >> Epigenetics >> JAK

Signaling Pathways >> Stem Cell/Wnt >> JAK

Research Areas >> Inflammation/Immunology

[Target]

IC50: 17 nM (JAK1), 23 nM (TYK2)[1]

[References]

[1]. Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₁F₂N₇O

[ Molecular Weight ]:
389.40

[ Storage condition ]:
2-8℃

Related Compounds