Glycinexylidide

Names

[ Name ]:
Glycinexylidide

[Synonym ]:
Glycinexylidide
2-AMINO-N-(2,6-DIMETHYLPHENYL)ACETAMIDE

Biological Activity

[Description]:

Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local anesthetic that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> MEK

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Strong JM, et al. Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide. Clin Pharmacol Ther. 1975 Feb;17(2):184-94.

Chemical & Physical Properties

[ Density]:
1.122g/cm3

[ Boiling Point ]:
323.5ºC at 760mmHg

[ Melting Point ]:
92 °C

[ Molecular Formula ]:
C₁₀H₁₄N₂O

[ Molecular Weight ]:
178.23

[ Flash Point ]:
149.4ºC

[ Exact Mass ]:
178.11100

[ PSA ]:
55.12000

[ LogP ]:
1.97390

[ Vapour Pressure ]:
0.000261mmHg at 25°C

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%