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Camptothecin-20(S)-O-propionate

Names

[ CAS No. ]:
194414-69-2

[ Name ]:
Camptothecin-20(S)-O-propionate

[Synonym ]:
SF 6A
UNII-4S145C552U
Camptothecin-20(S)-O-propionate
CZ48

Biological Activity

[Description]:

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[In Vivo]

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3]. Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect.

[References]

[1]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.

[2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9.

[3]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H20N2O5

[ Molecular Weight ]:
404.41500

[ Exact Mass ]:
404.13700

[ PSA ]:
87.49000

[ LogP ]:
3.04050

[ Storage condition ]:
-20°C

Related Compounds