2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

Names

[ CAS No. ]:
19504-77-9

[ Name ]:
2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

[Synonym ]:
Leofungine
Supral
EINECS 243-116-9
Pecilocin
variotin

Biological Activity

[Description]:

Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. MATSUDA A, et al. Studies on antifungal activity of variotin. J Antibiot (Tokyo). 1959 Sep;12:203-9.

Chemical & Physical Properties

[ Density]:
1.088g/cm3

[ Boiling Point ]:
481.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₅NO₃

[ Molecular Weight ]:
291.39

[ Flash Point ]:
244.8ºC

[ Exact Mass ]:
291.18300

[ PSA ]:
57.61000

[ LogP ]:
2.68310

[ Vapour Pressure ]:
2.79E-11mmHg at 25°C

[ Index of Refraction ]:
1.538

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5777000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (E,E,E)-(R)-

CAS REGISTRY NUMBER :: 19504-77-9

LAST UPDATED :: 198104

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O3

MOLECULAR WEIGHT :: 291.43

WISWESSER LINE NOTATION :: T5NVTJ AV1U2U1Y1&U1YQ4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2004,1978