FR198248

Names

[ CAS No. ]:
197316-54-4

[ Name ]:
FR198248

[Synonym ]:
1,5,6,7-Isobenzofurantetrol,1,3-dihydro-4-methyl
UNII-6ZL0C9ER7N

Biological Activity

[Description]:

FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC50 of 3.6 µM. FR198248 can be used for antiviral and antibacterial research[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[Target]

Influenza Virus, PDF[1][2].


[References]

[1]. Nishihara Y, et al. FR198248, a new anti-influenza agent isolated from Aspergillus terreus No. 13830 I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. The journal of antibiotics, 2001, 54(2): 136-143.

[2]. Kwon YJ, et al. Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase. Biosci Biotechnol Biochem. 2010;74(2):390-3.  

Chemical & Physical Properties

[ Molecular Formula ]:
C9H10O5

[ Molecular Weight ]:
198.17

[ Exact Mass ]:
198.05300

[ PSA ]:
97.99000

[ LogP ]:
0.41660

Related Compounds