2′-Deoxy-N-methylguanosine

Names

[ CAS No. ]:
19916-77-9

[ Name ]:
2′-Deoxy-N-methylguanosine

[Synonym ]:
N2-methyl-2'-deoxy-guanosine
2'-deoxy-2-N-methylguanosine
O6-Methyl-dG

Biological Activity

[Description]:

2’-Deoxy-N2-methylguanosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₅O₄

[ Molecular Weight ]:
281.27

[ Exact Mass ]:
281.11200

[ PSA ]:
125.29000

2′-Deoxy-N-methylguanosine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds