NSC95682

Names

[ CAS No. ]:
20035-41-0

[ Name ]:
NSC95682

[Synonym ]:
6-bromo-2-hydroxy-3-methoxy-benzaldehyde
6-bromo-3-methoxysalicylaldehyde
6-bromo-2-hydroxy-3methoxy-benzyldehyde
2-bromo-5-methoxy-6-hydroxybenzaldehyde
MFCD00046152
2-Hydroxy-3-methoxy-6bromo-benzaldehyde
6-BroMo-2-hydroxy-3-Methoxybenzaldehyde
NSC95682

Biological Activity

[Description]:

NSC95682 is an IRE-1α inhibitor with an IC50 of 0.08 μM, extracted from patent WO 2008154484 A1, IRE-lα inhibitor compound 3-5.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> IRE1

Research Areas >> Cancer

[Target]

IC50: 0.08 μM (IRE-1α)[1]

[References]

[1]. John Bruce Patterson, et al. Ire-1a inhibitors. WO 2008154484 A1

[Related Small Molecules]

STF-083010 | 4μ8C | KIRA6 | APY 29 | MKC3946 | GSK2850163 | MKC9989 | MKC8866 | B I09

Chemical & Physical Properties

[ Density]:
1.653g/cm3

[ Boiling Point ]:
282.1ºC at 760mmHg

[ Melting Point ]:
102-105 °C(lit.)

[ Molecular Formula ]:
C₈H₇BrO₃

[ Molecular Weight ]:
231.04300

[ Flash Point ]:
124.4ºC

[ Exact Mass ]:
229.95800

[ PSA ]:
46.53000

[ LogP ]:
1.97580

[ Vapour Pressure ]:
0.00201mmHg at 25°C

[ Index of Refraction ]:
1.622

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2913000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2913000090

[ Summary ]:
HS: 2913000090 halogenated, sulphonated, nitrated or nitrosated derivatives of products of heading 2912 Educational tariff:17.0% Tax rebate rate:9.0% Regulatory conditions:none Most favored nation tariff:5.5% General tariff:30.0%