DHODH-IN-7

Names

[ CAS No. ]:
2029049-77-0

[ Name ]:
DHODH-IN-7

Biological Activity

[Description]:

DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC50 of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase

[In Vitro]

The lysozyme-GFPER-HoxA9 murine cell line (ER-HOX-GFP) and the THP1 and U937 human AML cell lines were cultured with compounds in a 4-day differentiation assay. DHODH-IN-7 shows EC50s of 3.6, 2.7, and 2.5 μM for ER-HOX-GFP, THP1 and U937 human AML cell lines, respectively[1].

[References]

[1]. Lewis TA, et al. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Sep 28;7(12):1112-1117.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₁F₃N₂O₂

[ Molecular Weight ]:
390.40

Safety Information

[ Hazard Codes ]:
Xi

DHODH-IN-7

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds