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2',3'-O-Isopropylidene 5-hydroxyuridine

Names

[ CAS No. ]:
20406-82-0

[ Name ]:
2',3'-O-Isopropylidene 5-hydroxyuridine

[Synonym ]:
5-Hydroxy-2',3'-O-isopropylideneuridine
5-Hydroxy-1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrimidine-2,4-dione
5-hydroxy-O2',O3'-isopropylidene-uridine
2',3'-O-Isopropyliden-5-hydroxy-uridin

Biological Activity

[Description]:

2’,3’-Isopropylidene-5-hydroxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H16N2O7

[ Molecular Weight ]:
300.26

[ Exact Mass ]:
300.09600

[ PSA ]:
123.01000

Related Compounds