JAK-IN-24

Names

[ CAS No. ]:
2042629-43-4

[ Name ]:
JAK-IN-24

Biological Activity

[Description]:

JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Research Areas >> Inflammation/Immunology

[In Vitro]

JAK-IN-24 (Example 129) 在 4 μM 或 1mM ATP 存在时抑制 JAK 的 IC50 值分别为 0.534 和 24 nM[1]。 JAK-IN-24 在人全血中表现出稳定性，t1/2 为 267.223 分钟[1]。 JAK-IN-24 抑制 PBMC IL-15 诱导的 STAT5 磷酸化，IC50 为 86.171 nM[1]。

[References]

[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H25N5O2

[ Molecular Weight ]:
367.44

Related Compounds