1,2, 4-Triazine-3,5 (2H,4H)-dione, 2-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-

Names

[ CAS No. ]:
20500-29-2

[ Name ]:
1,2, 4-Triazine-3,5 (2H,4H)-dione, 2-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-

[Synonym ]:
6'-aza-2'deoxyuridine
6-Azauridine deoxyribonucleoside
2'-Deoxy-6-azauridine

Biological Activity

[Description]:

6-Aza-2'-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.9g/cm3

[ Molecular Formula ]:
C₈H₁₁N₃O₅

[ Molecular Weight ]:
229.19

[ Exact Mass ]:
229.07000

[ PSA ]:
117.44000

[ Index of Refraction ]:
1.753