Lenvervimab

Names

[ CAS No. ]:
2055006-79-4

[ Name ]:
Lenvervimab

Biological Activity

[Description]:

Lenvervimab (GC1102) is a IgG1-type recombinant human hepatitis B Immunoglobulin. Lenvervimab can be used for research of hepatitis B virus infection[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

Lenvervimab (1 nM-1 μM，16 小时) 抑制感染 HBV 的 HepG2-NTCP 细胞中的 HBV 感染[1]。 Lenvervimab 可识别 HBV 感染的许多病毒基因型和临床变异体[1]。 Western Blot Analysis[1] Cell Line: HepG2-NTCP cells infected with HBV Concentration: 1 nM-1 μM Incubation Time: 16 h Result: Inhibited viral expression of the surface antigen HBsAg (hepatitis B virus surface antigen) and the core protein HBcAg.

[References]

[1]. Jeong GU, et al. A recombinant human immunoglobulin with coherent avidity to hepatitis B virus surface antigens of various viral genotypes and clinical mutants. PLoS One. 2020 Aug 13;15(8):e0236704.

[2]. Lee HW, et al. Efficacy of Lenvervimab, a Recombinant Human Immunoglobulin, in Treatment of Chronic Hepatitis B Virus Infection. Clin Gastroenterol Hepatol. 2020 Dec;18(13):3043-3045.e1.

Chemical & Physical Properties

No Any Chemical & Physical Properties