IV-361
Names
[ CAS No. ]:
2055741-39-2
[ Name ]:
IV-361
Biological Activity
[Description]:
IV-361 is an orally active and selective CDK7 inhibitor (Ki≤50 nM). IV-361 has anti-cancer activity (US20190256531A1)[1].
[Related Catalog]:
[Target]
CDK7:≤50 nM (Ki)
CDK2:≥1000 nM (Ki)
[In Vitro]
IV-361 has less inhibition on CDK2 (Ki≥1000 nM) or PLK1 (Ki≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC50≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI50≤100 nM)[1].
[In Vivo]
IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H32FN5O2Si
[ Molecular Weight ]:
457.62