BAY-364

BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

BAY-364 (0.1-100 µM；3 d) 抑制 Kasumi-1 细胞、CD34+ 细胞和 K562 细胞的生长[1]。 BAY-364 (72 h) 降低了 Kasumi-1 细胞中 ID1、MYC 和 TAF1 的表达，而不影响 AE 的表达[1]。 BAY-364 (10 µM；2 d) 减少了 AE9a+ 细胞中的集落形成[1]。 BAY-364 (2 µM；48 h 和 72 h) 对 K562 细胞的细胞周期无显著影响[2]。 Cell Cycle Analysis[2] Cell Line: K562 cells. Concentration: 2 µM. Incubation Time: 48 h and 72 h. Result: Had insignificant effect on the cell cycle.

[1]. Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10(1):4925.  

[2]. Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.