α7 nAchR-JAK2-STAT3 agonist 1

Names

[ CAS No. ]:
2108714-20-9

[ Name ]:
α7 nAchR-JAK2-STAT3 agonist 1

Biological Activity

[Description]:

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.32 μM (NO)[1]


[References]

[1]. Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H30O6

[ Molecular Weight ]:
426.50

Related Compounds