ICRF-196

Names

[ Name ]:
ICRF-196

[Synonym ]:
C12H18N4O4
Icrf 193

Biological Activity

[Description]:

ICRF-196 is an racemic mixture of the (S,S)- and (R,R)-isomers of ICRF-193 (HY-118590). ICRF-193 is an TopoII inhibitor. ICRF-196 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Snapka RM,et al. Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration. Biochem Pharmacol. 1996;52(4):543-549.

Chemical & Physical Properties

[ Density]:
1.308g/cm3

[ Boiling Point ]:
526.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₈N₄O₄

[ Molecular Weight ]:
282.30

[ Flash Point ]:
272.4ºC

[ Exact Mass ]:
282.13300

[ PSA ]:
98.82000

[ Vapour Pressure ]:
3.48E-11mmHg at 25°C

[ Index of Refraction ]:
1.539

Safety Information

[ HS Code ]:
2933599090

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%