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3'-Azido-3'-deoxy-5-Methyuridine

Names

[ CAS No. ]:
215176-58-2

[ Name ]:
3'-Azido-3'-deoxy-5-Methyuridine

[Synonym ]:
1-((2R,3R,4S,5S)-4-Azido-3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
3'-azido-3'-deoxy-5-methyluridine
3'-azido-3'-deoxythymidine
1-(3'-azido-3'-deoxy-β-D-ribofuranosyl)thymine
1-(3-azido-3-deoxy-β-D-ribofuranosyl)thymine
AZT
3'-azido-3'-deoxy-β-ribosylthimine

Biological Activity

[Description]:

3’-Azido-3’-deoxy-5-methyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13N5O5

[ Molecular Weight ]:
283.24

[ Exact Mass ]:
283.09200

[ PSA ]:
154.30000

Related Compounds