5-(Trifluoromethyl)uridine

Names

[ CAS No. ]:
21618-67-7

[ Name ]:
5-(Trifluoromethyl)uridine

[Synonym ]:
5-trifluorouridine
500Mg,1g
5-trifluorothymidine
5-(trifluoromethyl)uridine

Biological Activity

[Description]:

5-(Trifluoromethyl)uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.765g/cm3

[ Molecular Formula ]:
C10H11F3N2O6

[ Molecular Weight ]:
312.20

[ Exact Mass ]:
312.05700

[ PSA ]:
124.78000

[ Index of Refraction ]:
1.563

Synthetic Route

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Related Compounds