ε-Amanitin

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin

Traditional Cytotoxic Agents

Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1].

[1]. Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1.

[2]. Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233.