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JH-XI-10-02

Names

[ CAS No. ]:
2209085-22-1

[ Name ]:
JH-XI-10-02

Biological Activity

[Description]:

JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PROTAC >> PROTAC

[Target]

CDK8:159 nM (IC50)

PROTAC


[References]

[1]. Hatcher JM, et al. Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Med Chem Lett. 2018 Mar 18;9(6):540-545.

Chemical & Physical Properties

[ Molecular Formula ]:
C53H69N5O9

[ Molecular Weight ]:
920.14

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds