PARP10-IN-3

Names

[ Name ]:
PARP10-IN-3

Biological Activity

[Description]:

PARP10-IN-3 is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. PARP10-IN-3 reveals potent inhibition on PARP2 and PARP15 with IC50s of 1.7 μM for human PARP2 and human PARP15, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

human PARP10:480 nM (IC50)

human PARP2:1.7 μM (IC50)

human PARP15:1.7 μM (IC50)

human TNKS2:6.5 μM (IC50)

human PARP4:7 μM (IC50)

human TNKS1:21 μM (IC50)

human PARP14:41 μM (IC50)

human PARP12:>10 μM (IC50)

human PARP16:>10 μM (IC50)

human PARP1:>100 μM (IC50)

human PARP3:>100 μM (IC50)

[In Vitro]

PARP10-IN-3 (化合物 20) 在 HeLa-PARP10 细胞中通过克隆形成测定 (CFA) 的 IC50 为 1-2 μM[1]。

[References]

[1]. Patricia Korn, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021 Oct;10(10):939-948.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₂N₂O₃

[ Molecular Weight ]:
256.26

[ Storage condition ]:
-20°C

PARP10-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds