Tubulin inhibitor 1
Names
[ CAS No. ]:
2237054-53-2
[ Name ]:
Tubulin inhibitor 1
Biological Activity
[Description]:
Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis[1].
[Related Catalog]:
[Target]
Tubulin[1]
[In Vitro]
Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization[1]. Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively[1]. Tubulin inhibitor 1 (40, 80, and 160 nM) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells[1].
[In Vivo]
Tubulin inhibitor 1 (50 mg/kg, i.p.) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H24N2O4
[ Molecular Weight ]:
368.43