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SJFα

Names

[ CAS No. ]:
2254609-27-1

[ Name ]:
SJFα

Biological Activity

[Description]:

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Signaling Pathways >> PROTAC >> PROTAC

[Target]

p38α:7.16 nM (DC50)

p38δ:299 nM (DC50)

PROTAC


[References]

[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.

Chemical & Physical Properties

[ Molecular Formula ]:
C59H67F2N7O11S

[ Molecular Weight ]:
1120.27

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds