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HDACs/mTOR Inhibitor 1

Names

[ CAS No. ]:
2271413-06-8

[ Name ]:
HDACs/mTOR Inhibitor 1

Biological Activity

[Description]:

HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC1:0.19 nM (IC50)

HDAC6:1.8 nM (IC50)

mTOR:1.2 nM (IC50)


[References]

[1]. Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H38N8O5

[ Molecular Weight ]:
566.65

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds