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NSC 135048

Names

[ CAS No. ]:
22733-60-4

[ Name ]:
NSC 135048

[Synonym ]:
Sicanina
Siccanine

Biological Activity

[Description]:

Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[Target]

Succinate Dehydrogenase Inhibitor


[In Vitro]

Siccanin (10 μg/mL) 具有物种选择性，Siccanin 抑制铜绿假单胞菌和恶臭假单胞菌的细菌 SDH，但不抑制大肠杆菌和谷氨酸棒杆菌的 SDH；Siccanin 抑制啮齿动物 SDH 但不抑制猪 SDH[1]。 具体而言，Siccanin 抑制铜绿假单胞菌（残留活性 13%）和恶臭假单胞菌（>1%）膜以及小鼠（>7%）和大鼠（19%）肝线粒体的 SDH，但不抑制大肠杆菌的 SDH (77%) 和谷氨酸棒杆菌 (97%) 膜和猪心脏线粒体 (106%)[1]。 Siccanin (3 μg/mL) 竞争性抑制须癣毛癣菌的生长 (IC50=0.3 μg/mL)[1]。

[References]

[1]. Mogi T, et al. Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor. J Biochem. 2009 Sep;146(3):383-7.  

Chemical & Physical Properties

[ Density]:
1.18g/cm3

[ Boiling Point ]:
427.8ºC at 760mmHg

[ Melting Point ]:
139-140°

[ Molecular Formula ]:
C22H30O3

[ Molecular Weight ]:
342.47

[ Flash Point ]:
212.5ºC

[ Exact Mass ]:
342.21900

[ PSA ]:
38.69000

[ LogP ]:
5.14570

[ Vapour Pressure ]:
6.41E-08mmHg at 25°C

[ Index of Refraction ]:
1.593

Related Compounds