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Polyoxin D

Names

[ CAS No. ]:
22976-86-9

[ Name ]:
Polyoxin D

[Synonym ]:
Polyoxin D,Streptomyces cacaoi var. asoensis
5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-β-D-allofuranuronic acid
5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido)-1-(5-carboxy-1,2,3,4-tetrahydro-2,4-dioxopyrimidin-1-yl)-1,5-dideoxy-β-D-allofuranuronic acid
polyoxin D
1-[5-[[(2-amino-5-carbamoyloxy-3,4-dihydroxypentanoyl)amino]-carboxymethyl]-3,4-dihydroxyoxolan-2-yl]-2,4-dioxopyrimidine-5-carboxylic acid
1-{5-[{[2-amino-5-(carbamoyloxy)-3,4-dihydroxypentanoyl]amino}(carboxy)methyl]-3,4-dihydroxytetrahydrofuran-2-yl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid(non-preferred name)

Biological Activity

[Description]:

Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. B Bowers, et al. Effect of polyoxin D on chitin synthesis and septum formation in Saccharomyces cerevisiae. J Bacteriol. 1974 Aug;119(2):564-75.

[2]. J M Becker, et al. Polyoxin D inhibits growth of zoopathogenic fungi. Antimicrob Agents Chemother. 1983 Jun;23(6):926-9.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C17H23N5O14

[ Molecular Weight ]:
521.39000

[ Exact Mass ]:
521.12400

[ PSA ]:
331.79000

[ LogP ]:
-2.48

[ Index of Refraction ]:
1.688

Related Compounds