KRAS G12C inhibitor 61

Names

[ CAS No. ]:
2300967-40-0

[ Name ]:
KRAS G12C inhibitor 61

Biological Activity

[Description]:

KRAS G12C inhibitor 61 (Example 3) inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC50 value of 9 nM. KRAS G12C inhibitor 61 can be used for research of pancreatic, colorectal, and lung cancers[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

K-Ras WT


[References]

[1]. Brian Alan Lanman, et al. Inhibitors of kras g12c and methods of using the same. Patent. WO2019051291.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H33ClFN7O2

[ Molecular Weight ]:
590.09

Related Compounds