Nicotinamide riboside chloride
Names
[ CAS No. ]:
23111-00-4
[ Name ]:
Nicotinamide riboside chloride
Biological Activity
[Description]:
Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements[1].
[Related Catalog]:
[Target]
SIRT1
SIRT3
[In Vitro]
Nicotinamide riboside chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2.
[In Vivo]
Chronic Nicotinamide riboside chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C11H15ClN2O5
[ Molecular Weight ]:
290.70000
[ Exact Mass ]:
290.06700
[ PSA ]:
116.89000
[ Storage condition ]:
2-8℃