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AD57 (hydrochloride)

Names

[ CAS No. ]:
2320261-72-9

[ Name ]:
AD57 (hydrochloride)

[Synonym ]:
1-[4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea hydrochloride (1:1)
AD57 (hydrochloride)
Urea, N-[4-[4-amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]-N'-[3-(trifluoromethyl)phenyl]-, hydrochloride (1:1)

Biological Activity

[Description]:

AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and Src[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src
Signaling Pathways >> MAPK/ERK Pathway >> Raf
Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[References]

[1]. Dar AC, et al. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 2012 Jun 6;486(7401):80-4.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H21ClF3N7O

[ Molecular Weight ]:
491.897

[ Exact Mass ]:
491.144806

Related Compounds