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Swertianolin

Names

[ CAS No. ]:
23445-00-3

[ Name ]:
Swertianolin

[Synonym ]:
5,8-Dihydroxy-3-methoxy-9-oxo-9H-xanthen-1-yl β-D-glucopyranoside
Sw-bromoacetophenone semicarbazone
2-bromo-1-phenyl-ethanone semicarbazone
bellidifolin 8-O-glucopyranoside
9H-Xanthen-9-one, 1-(β-D-glucopyranosyloxy)-5,8-dihydroxy-3-methoxy-
2-Brom-1-phenyl-aethanon-semicarbazon
SWERTIANOLIN
phenacyl bromide semicarbazone

Biological Activity

[Description]:

Swertianolin, a xanthone isolated from Gentianella Acuta, inhibits acetylcholinesterase (AChE). Swertianolin also exhibits anti-HBV and anti-bacterial activity[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Neuronal Signaling >> AChE
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Urbain A, et al. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4.

[2]. Xiu-Qiao Zhang, et al. Anti-HBV Activities of Xanthones From Swertia Punicea Hemsl. N A J Med Sci. 2014;7(2):72-74.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
806.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H20O11

[ Molecular Weight ]:
436.366

[ Flash Point ]:
287.7±27.8 °C

[ Exact Mass ]:
436.100555

[ PSA ]:
179.28000

[ LogP ]:
-1.13

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.705

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZD6057000
CHEMICAL NAME :
Xanthen-9-one, 5,8-dihydroxy-1-(beta-D-glucopyranosyloxy)-3-methoxy-
CAS REGISTRY NUMBER :
23445-00-3
LAST UPDATED :
199503
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H20-O11
MOLECULAR WEIGHT :
436.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
10 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985

Precursor & DownStream

Precursor

DownStream

Related Compounds